Pineapple Express

Seth Rogen

Dale Denton

James Franco

Saul Silver

Gary Cole

Ted

Danny McBride

Red

Rosie Perez

Carol

Kevin Corrigan

Budlofsky

Craig Robinson

Matheson

Amber Heard

Angie Anderson

Ed Begley Jr.

Robert

Nora Dunn

Shannon

Bobby Lee

Bobby

James Remar

General Bratt

Joe Lo Truglio

Mr. Edwards

Art Napiontek

Clark

Cleo King

Police Liaison Officer

Bill Hader

Private Miller

Jonathan Spencer

Scientist

Dana Lee

Cheung

Ken Jeong

Ken

David C. Cook

Chris Gebert

Howard S. Lefstein

Mark

Connie Sawyer

Faye Belogus

David McDivitt

Cop with Mole

Mae LaBorde

Mrs. Mendelson

Kendall Carly Browne

Old Woman

George Lew

Old Man

John Robert Tramutola

Walt

Adam Crosby

Ack

Andrew Heald

Blake

Jeannetta Arnette

Sandra Danby

Carlos Aleman

Guy in Car

Omar Leyva

Guy in Car #2

Sam Carson

Xerox Secretary

Jack Kehler

Walter - Accountant

Robert Longstreet

Dr. Terrence

Peter Gray Lewis

Thug #1 - Peter

Steve Bannos

Thug #2 - Jared

Eddie Rouse

Thug #5 - Lance

Mark Whigham

Thug #3

Brian Scannell

Thug

Troy Gentile

Troy (uncredited)

Jourdan Lee

Assassin (uncredited)