The Sisters Brothers

John C. Reilly

Eli Sisters

Joaquin Phoenix

Charlie Sisters

Jake Gyllenhaal

John Morris

Riz Ahmed

Hermann Kermit Warm

Rebecca Root

Mayfield

Allison Tolman

Girl Mayfield Saloon

Rutger Hauer

The Commodore

Carol Kane

Mrs Sisters

Patrice Cossonneau

Blount

Zac Abbott

Blount Guy Dying

David Gasman

Relay Owner

Philip Rosch

Storekeeper Pioneer Town 2

Creed Bratton

Quarrel Saloon Guy Town 02

Lenuta Bala

Woman with the Bortsch

Jochen Hägele

Horse Dealer Town 03

Eric Colvin

Horse Dealer Relay 02

Ian Reddington

The Father

Aldo Maland

Young Eli

Theo Exarchopoulos

Young Charlie

Sean Duggan

Jacksonville House Keeper

Raymond Waring

Mayfield Bartender

Jóhannes Haukur Jóhannesson

Head Trapper

Gerard Cooke

Storekeeper Mayfield

Frédéric Siuen

Pacific Chinese Dad Prospector

Trevor Allan Davies

Golden Pearl Valet

Aidan O'Hare

Horse Dealer American River

Andrew Litvack

Prospector

Nick Cornwall

Man Encampment Attacker 1

Duncan Lacroix

Man Encampment Attacker 2

Jean-Marc Bellu

Man Encampment Attacker 3

Diego Llano

American River Indian

Hugo Dillon

Dr Crane

Lexie Benbow-Hart

Dr Crane’s Daughter

Richard Brake

Rex

Kelda Holmes

Poor Woman Commodore