4:44 Last Day on Earth

Willem Dafoe

Cisco

Shanyn Leigh

Skye

Toni Redman

Man on phone (voice)

Pat Kiernan

News Anchor

Francis Kuipers

Teddy

Selena Mars

Skype Dancer

Justin Restivo

Suicide

Bojana Vasik

Woman with coat

Trung Nguyen

Delivery Boy

Triana Jackson

Cisco's Daughter

Dierdra McDowell

Cisco's Ex

Natasha Lyonne

Tina

Anita Pallenberg

Sky's Mother

Paul Hipp

Noah

José Solano

Drug Dealer

Judith Salazar

Friend of Dealer

Paz de la Huerta

Woman on Street

Frank Aquilino

Man Outside Bar

Maria Grazia Schirripa

Wailing Woman

Muriel Sprissler Dafoe

Cisco's Mother

Nicholas Deceolia

Man in Window

Tenzin Gyatso

Self (archive footage) (uncredited)

Al Gore

Self (archive footage) (uncredited)

Anthony Perullo

Contrition (uncredited)

Charlie Rose

Self (archive footage) (uncredited)

Tyler Stone

Man in Heels (uncredited)

Thomas Michael Sullivan

Priest (uncredited)

Nicola Tranquillino

Newscaster (uncredited)